Native to central Mexico, Opuntia microdasys alba inhabits sandy and gravelly soils at mid elevations. It is a polycarpic species with oval cladodes, distinguished by dense white glochids unlike other Opuntia species with yellow or red glochids. Oval cladodes 6-10 cm, compactly arranged; dense white glochids 1-2 mm long; light green color with paler shades during winter.
Full sun exposure; limited watering from autumn to spring; substrate with at least 70% well-draining mineral content; minimum temperature 5 °C; prone to rot if waterlogged.